Download Alzheimer's disease : methods and protocols by N M Hooper; Humana Press PDF

By N M Hooper; Humana Press

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Additional info for Alzheimer's disease : methods and protocols

Example text

Although association studies are simpler to conduct and may be capable of detecting minor susceptibility loci, they are less robust than linkage analysis and positive results are often less conclusive. Discrepancies arise through difficulties associated with deriving appropriately matched controls, lack of power, or through population specific effects. A selection of reported associations is outlined as follows, and illustrates some of the inconsistencies encountered in such studies. In view of the association of ApoE with sporadic AD, polymorphic variants of genes encoding proteins involved in lipid metabolism have been examined.

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Mol. Med. 2, 175–180. 33. Strittmatter, W. , Saunders, A. , Weisgraber, K. , Dong, L. , et al. (1994) Isoform specific interactions of Apolipoprotein E with microtubule associated protein tau: implications for Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 91, 11183–11186. 34. Huang, D. , Weisgraber, K. , Garner, C. , Saunders, A. , et al. (1994) Isoform-specific interactions of Apolipoprotein-E with the microtubule-associated protein MAP2c — implications for Alzheimer’s-disease. Neurosci. Lett.

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