By N M Hooper; Humana Press
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Although association studies are simpler to conduct and may be capable of detecting minor susceptibility loci, they are less robust than linkage analysis and positive results are often less conclusive. Discrepancies arise through difficulties associated with deriving appropriately matched controls, lack of power, or through population specific effects. A selection of reported associations is outlined as follows, and illustrates some of the inconsistencies encountered in such studies. In view of the association of ApoE with sporadic AD, polymorphic variants of genes encoding proteins involved in lipid metabolism have been examined.
Kamboh, M. , Lazo, J. , and Ferrell, R. E. (1998) Bleomycin hydroloase is associated with risk of sporadic Alzheimer’s disease. Nature Genet. 18, 211–212. 111. , Haines, J. , Scott, W. , et al. (1998) Analysis of the association between bleomycin hydrolase and Alzheimer ’s disease in Caucasians. Neurobiol. Aging 19, S68. 112. , Wilcox, M. , Laird, N. , Horvath, S. , Go, P. C. , et al. (1998) Alpha-2-macroglobulin is genetically asociated with Alzheimer’s disease. Nature Genet. 19, 357–360. Primary Drug Therapies for AD 45 3 Advances in Methodology and Current Prospects for Primary Drug Therapies for Alzheimer’s Disease David S.
Mol. Med. 2, 175–180. 33. Strittmatter, W. , Saunders, A. , Weisgraber, K. , Dong, L. , et al. (1994) Isoform specific interactions of Apolipoprotein E with microtubule associated protein tau: implications for Alzheimer’s disease. Proc. Natl. Acad. Sci. USA 91, 11183–11186. 34. Huang, D. , Weisgraber, K. , Garner, C. , Saunders, A. , et al. (1994) Isoform-specific interactions of Apolipoprotein-E with the microtubule-associated protein MAP2c — implications for Alzheimer’s-disease. Neurosci. Lett.