By Richard Fish, Peggy J. Danneman, Marilyn Brown, Alicia Karas
Because the booklet of the 1st variation, curiosity within the box has persevered to upward push, such a lot particularly in discomfort administration. Anesthesia and Analgesia in Laboratory Animals specializes in the exact anesthetic, analgesic, and post-operative care requisites linked to experimental surgical procedure. totally revised and up-to-date this re-creation presents the reader with brokers, equipment, and methods for anesthesia and analgesia that verify humane and winning procedural outcomes.ReviewReviews of First Edition:This lengthy awaited textual content is the 1st complete reference overlaying using anesthetics and analgesics for animals utilized in biomedical research... This ebook is a really very important reference for using animals in learn and is an important addition to the animal care and use library.--Mark Klinger in ASLAP NEWSLETTERI stumbled on the data in all parts accomplished and supported by means of certain citations. each facility that makes use of animals for study must have a duplicate of this ebook. all of the individuals will be congratulated on filling an enormous hole in wisdom, and in addition, filling it to a excessive standard.--LABORATORY ANIMALS...an in-depth, good written textual content on analgesia and anaesthesia of the laboratory animals that are meant to be welcome at the cabinets of laboratory veterinarians, researchers and technicians.--VETERINARY examine COMMUNICATIONSThis reference has fulfilled my expectancies of guides from the yank university of Laboratory Animal technological know-how. The examining is simple with a prepared stability of conception and practicality. This booklet is a useful reference for investigators, ethics committee contributors, laboratory animal practitioners, and veterinarians in perform. i like to recommend it wholeheartedly.--AUSTRALIAN VETERINARY magazine
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Extra resources for Anesthesia and Analgesia in Laboratory Animals
References . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . . I. INTRODUCTION The term “injectable anesthetic,” as applied to this chapter covers a broad range of substances with varied effects. The use of injectable anesthetics in laboratory animals is preferred by many for a variety of reasons: ease of administration, a widely available database supporting the use in laboratory animals, fewer specialized equipment needs, avoidance of endotracheal intubation, and fewer potential occupational health concerns for laboratory workers (Fish, 1997).
E. Romiﬁdine . . . . . . . . . . . . . . . . . . . . . . . . . . . F. Alpha2-Adrenoceptor Antagonists . . . . . . . . . . . . . . . . V. Dopaminergic Receptor Antagonists . . . . . . . . . . . . . . . . . A. Mechanism of Action and General Description . . . . . . . . . . . B. Phenothiazine Derivatives . . . . . . . . . . . . . . . . . . . . C.
Thiobarbiturates replace this oxygen atom with a sulfur atom, which confers greater lipid solubility. Generally speaking, a substitution such as sulfuration that increases lipid solubility is associated with greater hypnotic potency and more rapid onset, but shorter duration of action. Addition of a methyl group to the nitrogen atom of the barbituric acid ring, as with oxybarbiturate methohexital, also results in a compound with a short duration of action. Classiﬁcation of barbiturates as long, short, and ultrashort acting is no longer recommended, as it suggests that drug action ends abruptly after speciﬁed time periods; residual plasma concentrations and drug effects persist for several hours, even following anesthetic induction with “ultra-short acting” barbiturates (Stoelting and Hillier, 2006).