Download Berek and Hacker’s Gynecologic Oncology by Jonathan S. Berek MD MMS, Neville F. Hacker AM MD PDF

By Jonathan S. Berek MD MMS, Neville F. Hacker AM MD

Get the evidence-based, sensible counsel you must offer cutting-edge care to girls with gynecologic cancers. From analysis via clinical and surgical administration, Berek and Hacker's Gynecologic Oncology, sixth variation promises worthy wisdom and services on each point of gynecologic malignancies. perfect for gynecologic oncologists and fellows, common gynecologists, and clinical and radiation oncologists, this new version in actual fact interprets uncomplicated technology to medical perform, making it your go-to resource for daily reference.

  • Concise, accomplished insurance guarantees your entry to present wisdom of common rules, in addition to scientific and surgical operation for the whole variety of gynecologic cancers: cervical, breast, ovarian, vulvar and vaginal, and uterine.
  • Evidence-based, templated chapters velocity you on to the data you need.
  • Extensively revised, separate chapters at the most recent strategies in laparoscopy and robotics preserve you as much as date.
  • Expert authorship, together with the services of diverse overseas members, retains you on the vanguard of your box and is helping you arrange for board exams.
  • New illustrations and drawings, in addition to pathology slides and clinically-relevant diagrams, assist you visualize key concepts.
Now with the print version, benefit from the bundled interactive book version, supplying capsule, telephone, or on-line entry to:
  • Complete content material with more suitable navigation
  • A strong seek device that attracts effects from content material within the publication, your notes, or even the web
  • Cross-linked pages, references, and extra for simple navigation
  • Highlighting software for simpler reference of key content material in the course of the text
  • Ability to take and proportion notes with associates and colleagues

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Extra info for Berek and Hacker’s Gynecologic Oncology

Sample text

Other genes in the HR pathway are inactivated in some cancers and the HR pathway may be compromised in about half of the cases. Patients with BRCA1 or BRCA2 mutations have increased sensitivity to platinum chemotherapy and favorable survival relative to sporadic cases (197,198). Conversely, the emergence of platinum resistance in these cancers may occur as a result of “back mutations” in which the normal BRCA1 or BRCA2 sequence is restored (199). Cancers with defects in the double-stranded DNA HR repair pathway caused by mutations in BRCA1–2 or other genes can be targeted effectively by inducing a second hit in the form of inhibition of the single stranded DNA repair pathway.

It has been proposed that ovarian tumors can be classified as low-grade or high-grade based on histology, clinical behavior, and molecular phenotypes (136). Low-grade tumors are genetically stable and are characterized by mutations in a number of genes, including K-ras, BRAF, PTEN, and b-catenin. High-grade cancers, predominantly serous, have a high level of genetic instability and are characterized by mutation of TP53. There is strong evidence to suggest that all epithelial ovarian cancers have an extraovarian origin (137).

The mean age of onset of ovarian cancer in Lynch syndrome families is in the early 40s, and the clinical features of these cancers generally are more favorable than sporadic cases (79). They are usually early stage, well or moderately differentiated and approximately 20% occur in the setting of synchronous endometrial cancers. However, analysis of groups of patients with synchronous cancers of the ovary and endometrium has revealed that few of these exhibit microsatellite instability and most probably are not attributable to Lynch syndrome (80).

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