By George Coukos, Stephen C. Rubin
NTI/Sales replica: the single consultant to supply finished assurance of the administration of endometrial melanoma, in addition to cancers in, on, and round the uterus. stories the effect of diagnostic instruments, imaging concepts, and sampling systems within the overview and administration of varied cancers. Discusses past due and complex degree remedies together with radiation and surgical procedure.
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63. Chiaravalli AM, Furlan D, Facco C, et al. Immunohistochemical pattern of hMSH2/hMLH1 in familial and sporadic colorectal, gastric, endometrial and ovarian carcinomas with instability in microsatellite sequences. Virchows Arch 2001; 438:39–48. Coukos01 001-034 11/18/04 1:32 PM Page 25 Molecular Genetics of Uterine Malignancies 25 64. Esteller M, Levine R, Baylin SB, Ellenson LH, Herman JG. MLH1 promoter hypermethylation is associated with the microsatellite instability phenotype in sporadic endometrial carcinomas.
Mutation carriers are also at risk for multiple early-onset uterine leiomyoma (43). Although there are families in which PTEN mutation carriers have developed uterine cancers (44), an association between inherited PTEN mutation and increased risk for endometrial carcinoma has not been established. In summary, a small fraction of women with uterine cancers develop disease because of a major inherited genetic susceptibility. The syndromes and genes associated with inherited uterine cancer are summarized in Table 1.
Inherited susceptibility to uterine leiomyomas and renal cell cancer. A. 2001; 98:3387–3392. 35. Levy B, Mukherjee T, Hirschhorn K. Molecular cytogenetic analysis of uterine leiomyoma and leiomyosarcoma by comparative genomic hybridization. Cancer Genetics Cytogenet 2000; 121:1–8. 36. Quade BJ, Pinto AP, Howard DR, Peters WA, 3rd, Crum CP. Frequent loss of heterozygosity for chromosome 10 in uterine leiomyosarcoma in contrast to leiomyoma. Am J Pathol 1999; 154:945–950. 37. Tulinius H, Egilsson V, Olafsdottir GH, Sigvaldason H.