By Michael Alan Singer
This e-book describes a unique and new angle to the remedy of human illnesses in line with the examine of ordinary animal versions. A ordinary animal version is outlined as an animal crew or species that possesses a suite of biochemical/physiological features that are average and adaptive for that animal, yet are really irregular for people. for instance, how is it that birds can tolerate blood glucose concentrations which in people are linked to diabetes. The usual animal version resides evidence organic solution to this query is obtainable. via learning typical animal types, we will be able to achieve invaluable insights into the therapy of assorted human scientific issues. masking quite a lot of issues, this e-book describes intimately how scientific scientists can benefit from all of the "research" that nature has already played over billions of years in organic challenge fixing via broad animal layout checking out and choice.
Read or Download Comparative Physiology, Natural Animal Models and Clinical Medicine: Insights into Clinical Medicine from Animal Adaptations PDF
Best laboratory medicine books
Derek T. O'Hagan and a workforce of specialist vaccinologists and pharmacologists completely describe the practise, characterization, and overview of a variety of replacement vaccine adjuvants to be used in preclinical experiences. each one bankruptcy conscientiously experiences a unmarried adjuvant, and indicates why a selected adjuvant will be hottest for a given antigen, reckoning on what form of immune reaction is wanted.
The collaborative efforts of over one hundred forty skilled medical microbiologists, laboratory supervisors, and laboratory technologists are incorporated within the re-creation of the scientific Microbiology tactics guide. This well-respected reference maintains to function the only real significant e-book supplying step by step descriptions that let medical microbiologists and their staffs to accomplish all analyses and their regulate from the recept of the specimen to the ultimate record.
During this up to date moment variation of the a lot praised medical functions of PCR, major researchers observe molecular diagnostics to the numerous fresh advances that experience happened in polymerase chain response (PCR)-based applied sciences. Highlights comprise real-time PCR, which permits the strategy to be played in a quantitative demeanour with more advantageous sensitivity, robustness, and resilience to carryover infection, mass spectrometric research of nucleic acids, and circulating cell-free nucleic acids in plasma.
The purpose of this e-book is to enhance the administration of sufferers with, or more likely to enhance, osteoporosis it's meant as a realistic consultant for all future health execs serious about shared sufferer care
Additional info for Comparative Physiology, Natural Animal Models and Clinical Medicine: Insights into Clinical Medicine from Animal Adaptations
1997a. Glucose transporters of the glomerulus and the implications for diabetic nephropathy. Kidney Int. 52, Suppl. 60, S91–S99. , 1997b. D-glucose stimulates mesangial cell Glut 1 expression and basal and IGF-1 sensitive glucose uptake in rat mesangial cells. Implications for diabetic nephropathy. Diabetes 46, 1030–1039. , 1982. Glycosylated hemoglobin in human and animal red cells. Role of glucose permeability. Diabetes 31, 743–748. , 2001. Comparative biology of aging in birds: an update. Exper.
In both the mature avian and mammalian retinas, Muller cells express both VEGF and Flk1 forming an autocrine circuit. Given these apparent similarities between avian and mammalian Muller cells, why is Muller cell expression of VEGF in the bird not associated with retinal vascularization? Do the VEGF-Flk1 autocrine circuits in the bird and mammal have similar or dissimilar functions? Muller cells also express the Glut 1 transporter but there are no data as to whether this transporter is upregulated in diabetes.
These results clearly indicate that increased glucose transport activity with an increase in delivery of intracellular glucose is the critical step for enhanced ECM synthesis. Enhanced mesangial cell ECM synthesis would clearly play a critical role in the genesis of diabetic glomerulosclerosis. The role played by a high extracellular glucose concentration is to increase glucose transport activity by inducing an increased expression of the Glut 1 transporter. (b) Juxtaglomerular apparatus The elevated GFR observed in the early stages of diabetes has already been discussed.