By Christiane Richter-Landsberg
This precious new name addresses the function of warmth surprise proteins and mobile rigidity responses within the mind, with a big specialize in nerve cells and glia, particularly oligodendrocytes and astrocytes. warmth surprise proteins are serious about many physiological tactics, together with improvement and differentiation, organization of the cytoarchitecture by means of binding to cytoskeletal components, and law of the stability among phone demise and survival.
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Cell Stress Chaperones 1998; 3(4):228-236. 37. Concannon C G , Gorman A M , Samali A. O n the role of Hsp27 in regulating apoptosis. Apoptosis 2003; 8 ( l ) : 6 l - 7 0 . 38. Yoshida H , Kong YY, Yoshida R et al. Apafl is required for mitochondrial pathways of apoptosis and brain development. Cell 1998; 94(6):739-750. 39. Kuida K, Haydar T F , Kuan CY et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 1998; 94(3):325-337. 40. Kuida K, Zheng T S , N a S et al.
Their density correlated with the density of NFTs and it was suggested that aB-crystallin might be involved in the late, severe stage of pathogenesis. Our data further show that aB-crystallin but not HSP70 is mainly expressed in tauopathies with glial pathology. This enhanced expression of aB-crystallin seems to be specific for disorders with prominent glial pathology, suggesting distinct mechanisms for tau aggregation in neurons versus glia in neurodegenerative disorders. The molecular mechanisms leading to inclusion body formation and to cell death in oligodendrocytes are far from understood.
37. Concannon C G , Gorman A M , Samali A. O n the role of Hsp27 in regulating apoptosis. Apoptosis 2003; 8 ( l ) : 6 l - 7 0 . 38. Yoshida H , Kong YY, Yoshida R et al. Apafl is required for mitochondrial pathways of apoptosis and brain development. Cell 1998; 94(6):739-750. 39. Kuida K, Haydar T F , Kuan CY et al. Reduced apoptosis and cytochrome c-mediated caspase activation in mice lacking caspase 9. Cell 1998; 94(3):325-337. 40. Kuida K, Zheng T S , N a S et al. Decreased apoptosis in the brain and premature lethality in CPP32-deficient mice.