By Udo R. Markert
Being pregnant is a special symbiotic union among mom and fetus which contradicts some of the normal ideas of immunology. The maternal immune process reacts in the direction of the overseas tissue, yet rather than triggering rejection, it tolerates, helps and regulates its improvement. The immunological mechanisms permitting the fetus to develop and live on are complicated and will be tormented by inner and exterior components that could bring about being pregnant problems together with infertility, abortions and preeclamptic ailment. during this booklet, major scientists current the newest findings at the physiological mechanisms required for winning pregnancies, and the pathologies which may be attributable to a disturbance of those mechanisms. The law of maternal NK cells, T cells and dendritic cells via hormones, cytokines, the supplement approach and HLA in addition to different phone floor molecules is defined intimately.
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Extra info for Immunology of Pregnancy
Although the ␥-chain is shared with other inflammatory cytokines, such as IL-2, IL-6, IL-12, IL-15, IL-21 and others, the signaling pathway is different . IL-4 upregulates the transcription of GATA3 via STAT6, which leads to Th2 cytokine production and to a silencing of the IFN-␥ production [20, 26]. Mice lacking STAT6 exclusively develop a Th1 response . Poehlmann/Busch/Mussil/Winzer/Weinert/Mebes/Schaumann/Fitzgerald/Markert 28 Furthermore, IL-18 has been well characterized as a costimulatory factor for the induction of IL-12-mediated IFN-␥ production by Th1 cells, but it can also induce IL-4 production and thus facilitate the differentiation of Th2 cells.
Chem Immunol Allergy. Basel, Karger, 2005, vol 89, pp 26–35 The Possible Role of the JAK/STAT Pathway in Lymphocytes at the Fetomaternal Interface Tobias G. Poehlmann, Susann Busch, Bianka Mussil, Harald Winzer, Judith Weinert, Imke Mebes, Andreas Schaumann, Justine S. Fitzgerald, Udo R. Markert Department of Obstetrics, Friedrich Schiller University, Jena, Germany Abstract Pregnancy is accompanied by a Th2-prone immune modulation, which is a major puzzle piece among maternofetal tolerance-promoting factors.
103 Clark DA, Chaouat G, Arck PC, Mittruecker HW, Levy GA: Cytokine-dependent abortion in CBA ϫ DBA/2 mice is mediated by the procoagulant fgl2 prothrombinase (correction of prothombinase). J Immunol 1998;160:545–549. 104 Zenclussen AC, Joachim R, Hagen E, Peiser C, Klapp BF, Arck PC: Heme oxygenase is downregulated in stress-triggered and interleukin-12-mediated murine abortion. Scand J Immunol 2002; 55:560–569. Daniel Rukavina Department of Physiology and Immunology Medical Faculty, University of Rijeka, Brace Branchetta 20 HR–Rijeka 51 000 (Croatia), Tel.