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By Botros R. M. B. Rizk MD MA FACOG FACS FRCS, Juan A. Garcia-Velasco, Hassan N. Sallam, Antonis Makrigiannakis

Infertility and Assisted replica provides, intimately, the innovations and philosophies at the back of clinical approaches of infertility and assisted copy. World-class specialists of their box, representing learn from 18 assorted nations, have contributed to this groundbreaking textbook masking some of the most swiftly altering and hotly debated fields in medication. varied international locations have varied regulations at the examine thoughts that may be utilized to this box, and, for this reason, specialists from all over the world deliver assorted and special experts to various matters in reproductive expertise. This accomplished textbook encompasses the newest learn into the body structure of copy, infertility evaluate and remedy, and assisted copy and concludes with views at the moral dilemmas confronted through clinicians and execs. This ebook is designed to be a definitive source for these operating within the parts of reproductive drugs across the world.

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The main hormone product of the CL is progesterone, which induces the necessary endometrial modifications required for the acquisition of a receptive state, an anticipation of embryo implantation. The life span of the CL is limited. In a nonfertile cycle, corpora lutea regress at the end of the menstrual cycle and are eliminated by a process called luteolysis. If pregnancy does occur, regression must be inhibited since the CL is the main source of steroidogenesis, supporting the establishment and maintenance of a successful pregnancy.

Sasson R, Winder N, Kees S, Amsterdam A. 2002. Induction of apoptosis in granulosa cells by TNFa and its attenuation by glucocorticoids involve modulation of Bcl-2. Biochem Biophys Res Com 294:51–9. 34. Knudson CM, Tung KSK, Tourtellotte WG, et al. 1995. Baxdeficient mice with lymphoid hyperplasia and male germ cell death. Science 270:96–99. 35. Drummond EA. 2006. The role of steroids in follicular growth. Reprod Biol Endocrinol 4:16–26. 36. Robker RL, Russell DL, Espey LL, et al. 2000. Progesteroneregulated genes in the ovulation process: ADAMTS-1 and cathepsin L proteases.

The life span of the CL is limited. In a nonfertile cycle, corpora lutea regress at the end of the menstrual cycle and are eliminated by a process called luteolysis. If pregnancy does occur, regression must be inhibited since the CL is the main source of steroidogenesis, supporting the establishment and maintenance of a successful pregnancy. Although some of the biochemical and endocrine events characterizing the formation and regression of CL have been well established, the molecular aspects underlying luteinized granulosa cell (GC) migration and survival and the endocrine/paracrine mechanisms by which LH and hCG act on GCs to transform the ruptured follicle into the CL are not well characterized.

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