By C. William Helm, Robert Edwards
Intraperitoneal melanoma remedy investigates intraperitoneal chemotherapy in numerous advanced and engaging methods. the amount information significant scientific trails thus far, together with immunotherapy, hyperthermic remedy of colo-rectal and ovarian cancers. Authors additionally research local methods to remedy, systemic remedy, and using carboplatin and paclitaxel because the average therapy for ladies with levels III and IV ovarian melanoma. different chapters additionally examine concepts and strategies in remedy, in addition to the longer term path of either normothermic and hyperthermic intraperitoneal chemotherapy.
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Additional info for Intraperitoneal Cancer Therapy (Current Clinical Oncology)
PHASE II TRIAL EXPERIENCE WITH IP CISPLATIN IN OVARIAN CANCER Predictably, based on its central role in the management of ovarian cancer, much of the initial phase II trial effort (both single-agent and combination chemotherapy regimens) in the malignancy focused on cisplatin (30–37). Further, with few exceptions, the early phase II IP trials in ovarian cancer were directed toward treating women with this strategy as a “second-line” treatment approach. Exploration of the activity of IP cisplatin in this particular clinical setting permitted a most interesting, and rather unique, analysis.
The study by Markman (6) is particularly confounding because women allocated an IP component to their treatment also received an additional very high “priming” dose of IV carboplatin. Data on the risk of thrombocytopenia, leukopenia, renal toxicity, gastrointestinal toxicity, and neurological toxicity are heterogeneous and cannot be combined legitimately. However, data on fever, pain, infection, fatigue, and ototoxicity passed the test of homogeneity. 5 2 Favors IV Fig. 2. Forrest plot showing time from randomization to death (above) and time from randomization to recurrent disease (below).
Phase I and pharmacological studies of adriamycin administered intraperitoneally to patients with ovarian cancer. Cancer Res 1982;42:4265–4269. 7. Alberts DS, Surwit EA, Peng YM, et al. Phase I clinical and pharmacokinetic study of mitoxantrone given to patients by intraperitoneal administration. Cancer Res 1988;48: 5874–5877. 8. Howell SB, Pfeiﬂe CL, Wung WE, et al. Intraperitoneal cisplatin with systemic thiosulfate protection. Ann Intern Med 1982;97:845–851. 9. Lopez JA, Krikorian JG, Reich SD, et al.