By Derry Roopenian
With the common program of sturdy tissue and bone marrow transplantation as a remedy for an array of existence threatening problems, there's a urgent want for clinicians and experimentalists to appreciate the foundation of immunological rejection of tissue transplants. whereas a lot prior paintings makes a speciality of characterization of antigens encoded through the foremost histocompatibility complicated (MHC) during this procedure, the numerous histocompatibility (H) antigens encoded outdoor of the MHC, the so-called minor H antigens, have only in the near past been pointed out on the molecular point. This simply readable yet complete textual content is the 1st to place jointly insightful historical views with up to date advances within the molecular genetics, biochemistry and immunobiology of teen H antigens from either experimental and scientific issues of view. In doing so it presents a sourcebook relatively suited to clinicians and experimental immunologists engaged in tissue transplantation.
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Extra info for Minor Histocompatibility Antigens: From the Laboratory to the Clinic
Roopenian DC, Davis AP, Christianson GJ et al. The functional basis of minor histocompatibility loci. J Immunol 1993; 151:4595-4605. 48. Steinmuller D, Marcus JL, Bailey DW. The screening of non-H2 congenic lines for Sk loci. Immunogenetics 1978; 7:239-245. 49. Johnson LL, Bailey DW, Mobraaten LE. Genetics of histocompatibility in mice IV Detection of certain minor (non-H2) H antigens in selected organs by the popliteal node test. Immunogenetics 1981; 14:63-71. 50. Bailey DW. The vastness and organization of the murine histocompatibility-gene system as inferred from mutational data.
Upon closer study these were observed whenever the grafts were exchanged between males of reciprocal F1 hybrids. 24 Upon this discovery, F1 mice were no longer universal recipients; grafts would not survive when exchanged between reciprocal-type F1-hybrid males. Snell’s Laws had to be modified again. However, what about female grafts on males? We hadn’t made such grafts in the routine assays for mutants. 25 We could now test this hypothesis with HX. 18 This was evidence that the HX gene(s) had its effect at the cellular level.
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