By Antonio Giordano, Alessandro Bovicelli, Robert J. Kurman
Molecular Pathology of Gynecologic melanoma specializes in placing winning molecular ideas into perform for the remedy of gynecologic melanoma. the amount starts with an explication of the editors’ speculation that melanoma is principally a illness of the mobilephone cycle, in response to the deregulation of the physiological strategy of mobilephone replica. the next 11 chapters specialise in particular matters in gynecologic cancers, together with: a proposed version of ovarian serous carcinogenesis, molecular markers for ovarian epithelial melanoma, an summary of the pathology of endometrial melanoma, molecular genetic points of endometrial carcinoma and cervical melanoma, a average heritage of Human Papilloma Virus (HPV) because it pertains to cervical melanoma, and hereditary concerns in gynecologic cancers. The concluding bankruptcy proposes and descriptions a holistic method of the therapy of girl melanoma sufferers. This new quantity in Humana’s present scientific Oncology™ sequence can be worthwhile interpreting for clinicians and experimental researchers alike.
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Additional info for Molecular Pathology of Gynecologic Cancer (Current Clinical Oncology)
Am J Pathol 2001; 159: 817–824. 42. Urosevic M, Willers J, Mueller B, Kempf W, Burg G, Dummer R. HLA-G protein up-regulation in primary cutaneous lymphomas is associated with interleukin-10 expression in large cell T-cell lymphomas and indolent B-cell lymphomas. Blood 2002; 99: 609–617. 43. Tsuchiya A, Sakamoto M, Yasuda J, et al. Expression profiling in ovarian clear cell carcinoma: identification of hepatocyte nuclear factor-1beta as a molecular marker and a possible molecular target for therapy of ovarian clear cell carcinoma.
CA 125 has also been observed elevated in a variety of benign diseases, including endometriosis. Unfortunately, CA 125 is typically not sufficiently specific or sensitive for screening of the general population. For example, only 50% of stage I patients have CA 125 higher than 35 U/mL (8). In addition, benign gynecological conditions can lead to unacceptably high levels of false-positive tests (low specificity) in premenopausal women, although this problem is less significant in postmenopausal women.
From the Danish “Malova” Ovarian Cancer study. Gynecol Oncol 2003; 89: 31–36. 54. Obata K, Morland SJ, Watson RH, et al. Frequent PTEN/MMAC mutations in endometrioid but not serous or mucinous epithelial ovarian tumors. Cancer Res 1998; 58: 2095–2097. 55. Sato N, Tsunoda H, Nishida M, et al. 3 and mutation of the tumor suppressor gene PTEN in benign endometrial cyst of the ovary: possible sequence progression from benign endometrial cyst to endometrioid carcinoma and clear cell carcinoma of the ovary.