By Dean H. Percy
Pathology of Laboratory Rodents and Rabbits has turn into a customary textual content for either veterinary pathologists and veterinarians in laboratory animal medication. Newly well-known infectious ailments proceed to emerge and molecular tools for learning infectious brokers have gotten ordinary for the class of those and formerly recognized pathogens. With the continuing improvement and perfection of genetic engineering thoughts, using genetically engineered mice within the examine laboratory maintains to develop exponentially.
This re-creation good points updates all through with elevated emphasis on well timed themes similar to infectious ailments in genetically engineered mice. ailments lined comprise viral infections, bacterial infections, parasitic illnesses, dietary and metabolic issues, behavioral problems, getting older and degenerative issues, environment-related disorder, and neoplasms. prepared by means of species, assurance comprises mice, rats, hamsters, gerbils, guinea pigs, and rabbits. Veterinary pathologists, laboratory animal veterinarians, and scholars will delight in the concise association and simply obtainable info on key diagnostic beneficial properties, differential diagnoses, and value of diseases.Content:
Chapter 1 Mouse (pages 3–124):
Chapter 2 Rat (pages 125–177):
Chapter three Hamster (pages 179–205):
Chapter four Gerbil (pages 207–216):
Chapter five Guinea Pig (pages 217–251):
Chapter 6 Rabbit (pages 253–307):
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Additional resources for Pathology of Laboratory Rodents and Rabbits, Third Edition
Mice infected in utero or as neonates are immunetolerant to LCMV and do not efficiently seroconvert, or circulating antibody is complexed with antigen. Adult mice infected with docile types of virus may have immune exhaustion, and not seroconvert. Thus, serological testing must be applied to a large sample size and can be enhanced by co-housing adult sentinel mice with mice suspected to be persistently infected. LCMV can be confirmed in suspect tissues with a variety of bioassay approaches, such as MAP testing, but this has been supplanted by PCR.
FIG. 21. Multifocal necrotizing hepatitis and splenitis in mouse during the acute phase of a natural infection with ectromelia virus. by doubling hematoxylin-staining time. Lymphoid tissue can be hyperplastic and/or focally necrotic, with occasional eosinophilic cytoplasmic inclusion bodies (type A pox inclusions or Marchal bodies). Erosive enteritis, often in association with Peyer’s patches, is common, with type A inclusions in enterocytes. Skin lesions consist of focal epidermal hyperplasia, with hypertrophy and ballooning of epithelial cells and formation of numerous prominent large type A inclusions (Fig.
Chronic illness in older mice must be differentiated from generalized lymphoproliferative disorders, amyloidosis, glomerulonephritis, and chronic renal disease of aging mice. Significance The overwhelmingly significant feature of LCMV is its zoonotic potential. This is enhanced when infections 30 CHAPTER 1 involve laboratory hamsters or immunodeficient mice. It can be predicted that T cell-deficient mice will amplify LCMV infection, and natural infection of athymic nude mice has been associated with human exposure.