Download Prognostic and Predictive Factors in Gynecologic Cancers by Charles F. Levenback, Anil Sood, Karen H Lu, Robert Coleman PDF

By Charles F. Levenback, Anil Sood, Karen H Lu, Robert Coleman

Prognostic and Predictive components in Gynecologic Oncology takes a clean examine a serious point of melanoma remedy making plans. a global staff of authors stories the conventional prognostic and predictive components comparable to tumor grade, histologic subtype, and grade after which is going a step additional to check the starting to be variety of molecular discoveries that experience expanding scientific value. The booklet is geared up into entire sections on ovarian, endometrial and cervical melanoma and comprises modern experiences, newly came upon molecular pathways, genetic markers, molecular imaging options, and their relevance to medical medicine.

Prognostic and Predictive elements in Gynecologic Oncology is illustrated with over a hundred figures and is key interpreting for oncologists, translational and easy scientists, in addition to fellows, citizens and scholars with a different curiosity in gynecologic oncology.

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Gynecol Oncol 1997;64:196–206. 29. The risk of cancer associated with specific mutations of BRCA1 and BRCA2 among Ashkenazi Jews. N Engl J Med 1997;336:1401–8. 19. Bandera CA, Muto MG, Welch WR, et al. Genetic imbalance on chromosome 17 in papillary serous carcinoma of the peritoneum. Oncogene 1998;16:3455–9. 30. Risch HA, McLaughlin JR, Cole DE, et al. Prevalence and penetrance of germline BRCA1 and BRCA2 mutations in a population series of 649 women with ovarian cancer. Am J Hum Genet 2001;68:700–10.

The presence of a BRCA mutation was associated with a 25% reduction in the relative risk of death when compared with sporadic cancers, and was noted to be an independent prognostic factor among patients with stage III tumors. In the study by Boyd et al,25 selection bias was avoided by utilizing all cases from a large consecutive series of ovarian cancer patients using archival material, thereby eliminating preferential inclusion of living patients in the mutation-carrier group. In addition, treatment-related differences were also minimized, given the use of patients and controls treated at the same institution over the same period of time.

Should women with familial ovarian cancer undergo prophylactic oophorectomy? Obstet Gynecol 1992;80:700–7. 5. Koch M, Gaedke H, Jenkins H. Family history of ovarian cancer patients: a case–control study. Int J Epidemiol 1989;18:782–5. 11. Schildkraut JM, Risch N, Thompson WD. Evaluating genetic association among ovarian, breast, and endometrial cancer: evidence for a breast/ovarian cancer relationship. Am J Hum Genet 1989;45: 521–9. 6. Hartge P, Schiffman MH, Hoover R, et al. Am J Obstet Gynecol 1989;161:10–16.

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