By Isabel Stabile, J. G. Grudzinskas, T. Chard (auth.), Isabel Stabile PhD, MRCOG, J. G. Grudzinskas MD, FRCOG, FRACOG, T. Chard MD, FRCOG (eds.)
Sixteen British experts pool their wide wisdom of spontaneous abortion in a single resource. Their dialogue is at once acceptable to medical events and is helping determine components of dialogue and substitute methods.
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16 British experts pool their huge wisdom of spontaneous abortion in a single resource. Their dialogue is without delay acceptable to scientific occasions and is helping establish parts of dialogue and substitute tools.
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Extra info for Spontaneous Abortion: Diagnosis and Treatment
This is now known to be untrue for women who discontinue oral contraceptives before conception (see Simpson 1985), as well as those exposed to spermicides prior to or after conception (Mills et al. 1985). Trauma Women commonly attribute pregnancy losses to trauma, such as a fall or a blow to the abdomen. However, fetuses are actually well protected from external Pathological Findings in First Trimester Abortuses 41 trauma by intervening maternal structures and ammo tic fluid: witness, for example, the relative safety of amniocentesis and chorionic villus sampling.
Questions that remain unanswered include (1) Are prevalence rates influenced by numbers of previous losses? (2) Does occurrence of both first- and second-trimester losses affect prevalence rates? If a balanced translocation is detected, antenatal cytogenetic studies should obviously be offered in subsequent pregnancies. The frequency of unbalanced fetuses at 16 weeks (amniocentesis) is far lower if the balanced translocation is acertained through repetitive abortions (perhaps 3%) than if ascertained through an anomalous live born (approximately 12%) (Daniels et al.
1985). Another study showed higher concentrations of progesterone receptor accompanied by low serum progesterone in patients with an out-ofphase endometrial biopsy (Saracoglu et al. 1985). However, perturbations in endometrial receptors have not yet been correlated with actual pregnancy loss. Given such arguable studies concerning diagnostic criteria for LPD, it is hardly surprising that no randomised studies exist to document efficacy of proffered therapeutic regimens, principally progesterone.