By Laurent Lescaudron, Julien Rossignol, Gary L. Dunbar
This ebook explores the opportunity of stem cells for ameliorating the standard of lifetime of sufferers with neurological and neurodegenerative ailments. It discusses result of pre-clinical investigations and case reports at the results of stem cellphone transplantation on phone loss of life, in addition to to promote/stimulate neuroprotection after mind and spinal wire damage via trophic aid, mobile alternative and remyelination. The ebook covers the upkeep of the stability among stem cells and their progenitors inside of their area of interest, either less than common and degenerative strategies and with ischemic stroke, a number of sclerosis, and mind tumor.
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Direct conversion of fibroblasts to functional neurons by defined factors. Nature 463: 1035–1041. B. H. (2011). Cell transplantation and gene therapy in Parkinson’s disease. Mt Sinai J. Med. 78: 126–158. , Woolf, T. and Pang, K. (1995). Induction of dopaminergic neuron phenotype in the midbrain by Sonic hedgehog protein. Nat. Med. 1: 1184–1188. Weisman, D. and McKeith, I. (2007). Dementia with Lewy bodies. Semin. Neurol. 27: 42–47. C. A. (1996). Multipotent CNS stem cells are present in the adult mammalian spinal cord and ventricular neuroaxis.
Clinical Transplantation of Stem Cells in HD. , 2010 Whole Ganglionic Eminence Whole Ganglionic Eminence Lateral Ventricular Eminence containing striatal primordia Fetal Neuronal Tissue Whole Ganglionic Eminence Fetal Neuronal Tissue Fetal Lateral Ganglionic Eminence Grafts underwent disease-like neuronal degeneration. Cortical hemorrhage, subdural hematoma following surgery Clinical Improvement for UHDRS for 2 years. Three mass lesions and one large Patient died 121 months following surgery cyst were present on the left from complications of advanced HD.
2011). , 2010). , 2011). This new technology is especially promising for the treatment of HD in that genetically engineering MSCs to release RNAi does not interfere with their growth, capacity to differentiate, or disrupt the normal karyotype of the cells. Theoretically, combining the beneficial effects of RNAi with the propensity of MSCs to create a favorable microenvironment through the release of anti-inflammatory cytokines and neurotrophic factors provides great therapeutic promise for the treatment of HD.