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By S.C.J. van der Putte

The unforeseen effects from an research into hereditary congenital anorectal malformations of pig embryos have established the weak spot of prior interpretations and structures and underlined the want for a brand new inquiry into the traditional improvement of the realm in human embryos. It confirmed that even though facts from malformations may perhaps supply additional information regarding the conventional improvement of the world, nice care should be taken in utilizing that info for the reconstruction of its common improvement which can be firmly in line with the statement of the evolving microscopic anatomy of the area within the first position.

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Additional info for The Development of the Perineum in the Human: A Comprehensive Histological Study with a Special Reference to the Role of the Stromal Components (Advances in Anatomy, Embryology and Cell Biology)

Example text

This temporary situation is apparently the result of a rapidly and markedly broadening epithelium within a narrowing passage. At most, a small focal adherence between the opposing surfaces may occur. It is evident from these observations that an “imperforate anal membrane” cannot be considered a cause for most types of anorectal malformations as is generally assumed. It should be stressed that the present observations clearly demonstrate that the anal canal has a character of its own which is quite different from the adjacent rectum as the most distal part of the intestine, and should not be designated as “rectum” as is almost general practice.

11, Epidermis. In c and d the depression deepens and narrows, adding a new superficial anal segment (6) with a new anal orifice to the original primary anal canal, which now forms the deep anal segment (1). 3, Rectum. Arrowhead, narrowing within the deep segment associated with the distal ends of the muscularis of the rectum; arrows, early anal crypts. 19 mm). The distal extremity of this muscularis propria bends inward and strikingly narrows the cloaca-derived deep segment of the anal canal at a short distance cranially to where the segment passes into the labia-related superficial anal segment (Fig.

17 mm). External to the rapidly disappearing remnants of the cloacal membrane, the originally shallow groove between flattened dorsal parts of the cloacal labia deepens and forms a sort of depression; simultaneously the midperineal region increases in volume to constitute a ventral wall (Fig. 16b). sq. epithelium similar to the epithelium which forms the inner lining of the rest of the cloacal labia. Following events demonstrate that these two segments deep and superficial to the now disintegrated cloacal membrane will form the structurally different cloaca-derived deep and labia-related superficial segments of the anal canal (Fig.

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