Download The Handbook of Experimental Animals - The Laboratory by Sonia Wolfe-Coote PDF

By Sonia Wolfe-Coote

A quantity within the guide of Experimental Animals sequence, The Laboratory Primate info the previous and current use of primates in biomedical learn, and the husbandry, dietary necessities, behaviour, and breeding of every of the widely used species. sensible details on regulatory specifications, no longer on hand in different texts, is roofed. Sections on experimental versions disguise the most important parts of biomedical examine, together with AIDS, melanoma, neurobiology and gene treatment. Assisted reproductive expertise, tissue typing, and minimal staff sizes for infectious disease/vaccine stories also are integrated. * Two-color, ordinary layout, with copious illustrations and colour plates* contains particular, well-illustrated sections on gross & microscopic anatomy, universal illnesses, and unique methods, together with surgical strategies

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To support this hypothesis, we cloned a portion of a novel ten-repeat allele of the human DAT gene and discovered a DraI restriction site-sensitive SNP. If particular alleles of the DAT gene differentially contribute to altered levels of DAT protein, it is important to consider both types of polymorphisms as potential modulators. Based on these considerations, and using a reporter assay, we investigated whether both the number of repeat sequences and the particular SNPs, in the 3′-UTR of the human and rhesus monkey DAT genes, could modify levels of gene expression (Miller and Madras, 2002).

Both the human DAT mRNA and rhesus monkey DAT mRNA have a tandem repeat region and single nucleotide polymorphisms. The coding region is shown in black and the 3′-untranslated region is shown in white. The location of the tandem repeat regions (open boxes) and the single nucleotide polymorphisms (T/C, human; T/G, monkey) that alter restriction endonuclease-sensitive sequences for DraI (human) and Bst1107I (rhesus monkey) are also shown. B (bottom): The effects of polymorphisms of human and rhesus monkey 3′-untranslated regions on luciferase reporter gene expression.

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