Download The Nuclear Receptor FactsBook by Vincent Laudet PDF

By Vincent Laudet

The FactsBook sequence has proven itself because the top resource of simply available and exact evidence approximately protein teams. They use an easy-to-follow layout and are researched and compiled by way of specialists within the box. This Factsbook is dedicated to nuclear receptors. the 1st part provides an creation and describes the mode of motion of the receptors typically. the second one component to the ebook includes distinct entries protecting each one form of receptor. Entries supply info on: Nomenclature and constitution Isolation DNA binding houses Ligands Expression objective genes Knockouts affliction organization Gene constitution, promoter and isoforms Chromosomal position Amino acid sequences Key references

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And Chambon, P. (1994) J. Biol. Chem. 269, 890-902. 40 Chen, H. et al. (1993) Mol. Cell Biol. 13, 2366-2376. W. L. (1993) Mol. Cell Biol. 13, 5970-5980. M. et al. (1992) Mol. Endocrinol. 6, 429-442. K. (1987) Nature 329, 738-741. K. et al. (1988) Cell 54, 313-323. 45 Sap, J. et al. (1989) Nature 340, 242-244. L. and Morkin, E. (1990) J. Biol. Chem. 265, 11233-11237. 47 Izumo, S. and Mahdavi, V. (1988) Nature 334, 539-542. 48 Desvergne, B. et al. (1991) J. Biol. Chem. 266, 1008-1013. W. J. (1993) J.

5, 199-202. 49 Le Douarin, B. et al. (1996) EMBO J. 15, 6701-6715. M. et al. (1997) Nature 387, 733-736. J. et al. (1998) EMBO J. 17, 507-519. D. et al. (1998) Genes Dev. 12, 3343-3356. T. et al. (1998) Nature 395, 137-143. K. et al. (1998) Cell 95, 927-937. '^ Bourguet, W. et al. (2000) Mol. Cell 5, 289-298. 56 Hu, X. A. (1999) Nature 402, 93-96. 57 Nagy, L. et al. (1999) Genes Dev. 13, 3209-3216. General organization of nuclear receptors 5s 59 60 6^ 62 63 6^ 65 ^^ 67 6« 69 70 71 72 73 74 75 76 ^^ 78 79 80 81 82 83 84 85 86 87 88 89 90 91 92 93 94 Perissi, V.

Such differences could be further enhanced by cooperative D N A binding with other promoter-bound factors and could contribute to the ability of a given target gene to respond preferentially to a particular signaling pathway. The orientation of the half-site motifs Like other receptors, TRs are able to bind to a palindromic element called the TREpaP^-^^, but such an element has not been reported in cellular genes. Furthermore, this element confers no hormonal specificity, since it can be recognized by a large number of other receptors.

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