Download The Sperm Cell, Production, Maturation, Fertilization, by Christopher J. De Jonge, Christopher Barratt PDF

By Christopher J. De Jonge, Christopher Barratt

Initially released in 2006, this can be a accomplished and definitive account of the human male gamete. the quantity summarizes many detailed and revealing features of the sperm cellphone. It offers a close evaluate of human sperm creation, maturation and serve as, and appears at how those procedures impact and effect fertility, infertility and paintings. the quantity therefore presents a close evaluation of an important examine and advancements, augmented with pertinent references. This ebook will entice all practitioners and scientists in reproductive medication and specifically to scientific scientists, graduate and post-graduate scientists, and laboratory team of workers.

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A) An unusual curvature of the AC (arrow), perhaps a consequence of aberrant chromatin condensation in the corresponding region of the nucleus, is observed in this otherwise normal spermatozoon. (B) Longitudinal section of the proximal centriole (asterisk) and proximal centriolar adjunct (arrow), an extension of the centriolar microtubule triplets often seen in human spermatozoa. (C) Cross-section of basal plate (arrowheads), proximal centriole (asterisk) and a striated column (arrows). (D) Abnormal spermatozoon with a connecting piece defect (arrow) and prominent nuclear vacuoles (arrowheads), containing trapped cytoplasm (see also Plate 1B).

2002). , 2004). , 1996). Reciprocally, the oocyte centrosome does not contain centrioles, while the ooplasm is stocked with protein constituents of pericentriolar material and other proteins necessary for de novo centriole biogenesis. The sperm centriole thus attracts maternal pericentriolar material with microtubule nucleating proteins from the ooplasm. , 1998), and pronuclear apposition relies exclusively on maternallycontrolled asters. , 1999c, 2004b). Oocyte mitochondria contribute all energy and mitochondrial genes to the zygote, a strategy that may be advantageous due to 22 Peter Sutovsky and Gaurishankar Manandhar 23 Mammalian spermatogenesis and sperm structure the volatile and potentially mutagenic environment to which paternal sperm mitochondria are exposed during sperm maturation, insemination and fertilization.

2000; Wykes and Krawetz, 2003b). It is not clear what parts of the sperm chromatin remain bound to histones after the condensation process, but it is reasonable to argue that the replacement would not be complete. This is important because DNA that is bound to histones is much more susceptible to DNA damaging agents than DNA that is bound to protamines. Therefore, the sperm chromatin that is bound to histones would be candidate loci for sperm DNA damage. The last point about sperm chromatin structure that we would like to present is what is known about the overall chromatin structure.

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