By Institute of Medicine, Division of Health Promotion and Disease Prevention, Committee to Review the Health Effects in Vietnam Veterans of Exposure to Herbicides (Third Biennial Update)
In 2001, based on a request by way of the U.S. division of Veterans Affairs (DVA), the Institute of drugs (IOM) known as jointly a committee to behavior a overview of the medical facts in regards to the organization among publicity to dioxin and different chemicals in herbicides utilized in Vietnam and acute myelogenous leukemia within the offspring of Vietnam veterans. in keeping with the clinical facts reviewed during this record, the committee unearths there's insufficient or inadequate facts to figure out if an organization exists among publicity to the herbicides utilized in Vietnam or their contaminants and acute myelogenous leukemia (AML) within the teenagers of Vietnam veterans. it is a switch in type from the hot Veterans and Agent Orange: replace 2000 document, which stumbled on limited/suggestive facts for such an association.
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Additional info for Veterans and Agent Orange: Herbicide/Dioxin Exposure and Acute Myelogenous Leukemia in the Children of Vietnam Veterans
CDVA (Commonwealth Department of Veterans’ Affairs). 1998. Morbidity of Vietnam Veterans: A Study of the Health of Australia’s Vietnam Veteran Community. Vol. 1: Male Vietnam Veterans Survey and Community Comparison Outcomes. Canberra: Department of Veterans’ Affairs. Erickson JD, Mulinare J, McClain PW, Fitch TG, James LM, McClearn AB, Adams MJ. 1984. Vietnam veterans’ risks for fathering babies with birth defects. Journal of the American Medical Association 252(7):903–912. Field B, Kerr C. 1988.
The number of cases of AML among the offspring of Australian veterans who served in Vietnam and whose diagnoses were validated in the study was unchanged (n = 9). The predicted numbers of cases under various assumptions regarding non-respondents and cases not able to be validated changed slightly, yielding a total of 12 cases in veterans’ children under the assumptions adopted by the authors. Two leukemia cases were also reclassified after further investigation: one case of CLL in veterans’ children was reclassified to AML and one case of AML was reclassified to ALL.
The Committee is not aware of any information published since the release of Update 2000 that bears on the issue of the biologic plausibility of any association between paternal exposure to the herbicides used in Vietnam or dioxin and AML in offspring. Given the present lack of information, the committee believes that further research aimed at evaluating long-term effects of herbicide exposures on male reproductive organs and on understanding the effects on sex ratio and functional developmental toxicities would be useful.